Gene information
Official symbol MPO
Official full name myeloperoxidase
Gene type protein-coding gene
Chromosome17q22
Resources
Entrez Gene 4353
HGNC HGNC:7218
Ensembl ENSG00000005381
Vega OTTHUMG00000178922
UCSC uc002ivu.1
GO terms: 59 records
GO Description Category LogP Number of genes Detail
GO:0000302 response to reactive oxygen species GO Biological Processes -13.4775134 34 More
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001878 response to yeast GO Biological Processes -4.12631862 3 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0004601 peroxidase activity GO Molecular Functions -5.52369866 7 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005766 primary lysosome GO Cellular Components -4.39854337 10 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0006801 superoxide metabolic process GO Biological Processes -5.35296451 10 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009620 response to fungus GO Biological Processes -9.57465113 11 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0016209 antioxidant activity GO Molecular Functions -11.3593886 22 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO Molecular Functions -5.30702712 7 More
GO:0019430 removal of superoxide radicals GO Biological Processes -5.14025860 6 More
GO:0020037 heme binding GO Molecular Functions -15.4577568 20 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034374 low-density lipoprotein particle remodeling GO Biological Processes -13.3517229 9 More
GO:0034599 cellular response to oxidative stress GO Biological Processes -11.6255265 36 More
GO:0034614 cellular response to reactive oxygen species GO Biological Processes -9.93259803 24 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035578 azurophil granule lumen GO Cellular Components -4.57928114 8 More
GO:0042582 azurophil granule GO Cellular Components -4.39854337 10 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0042743 hydrogen peroxide metabolic process GO Biological Processes -7.46259907 8 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0045335 phagocytic vesicle GO Cellular Components -3.63275570 16 More
GO:0046906 tetrapyrrole binding GO Molecular Functions -14.8570803 20 More
GO:0050832 defense response to fungus GO Biological Processes -7.96091962 9 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0071450 cellular response to oxygen radical GO Biological Processes -4.70690316 6 More
GO:0071451 cellular response to superoxide GO Biological Processes -4.70690316 6 More
GO:0071682 endocytic vesicle lumen GO Cellular Components -9.48174775 8 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0072593 reactive oxygen species metabolic process GO Biological Processes -9.21564496 21 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0097237 cellular response to toxic substance GO Biological Processes -13.7473733 28 More
GO:0098754 detoxification GO Biological Processes -12.4136065 17 More
GO:0098869 cellular oxidant detoxification GO Biological Processes -12.6410846 24 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903409 reactive oxygen species biosynthetic process GO Biological Processes -4.70690316 6 More
GO:1990748 cellular detoxification GO Biological Processes -12.8821364 16 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa04145 Phagosome KEGG Pathway -11.4012504 17 More
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05221 Acute myeloid leukemia KEGG Pathway -2.91912787 5 More
Drug-Gene interaction
view
Related drugs: 19 records
Drug name Interaction type Source PMID View
asulacrine NCI 1333205 view
diclofenac NCI 2173589 view
dimethyl sulfoxide NCI 1845843 view
doxycycline NCI 14564835 view
fentanyl NCI 8391745 view
fludarabine NCI 15608444 view
flutamide NCI 16330533 view
lidocaine NCI 8973808 view
lithium NCI 8224362 view
loratadine NCI 17159802 view
nimesulide NCI 17176264 view
octreotide NCI 15003363 view
propylthiouracil DTC 26509551 view
psoralen NCI 15865234 view
pyrazinamide NCI 2832129 view
tenecteplase NCI 16650886 view
theophylline NCI 8630596 view
tolmetin NCI 6266970 view
trimethoprim NCI 7425598 view
Related studies: 28 records
Molecular factor Omics type Application Objective MI type Reference
myeloperoxidase proteomics death[prognosis (bad)] acute myocardial infarction Mocatta TJ et al. J Am Coll Cardiol. 2007
myeloperoxidase proteomics good predictor acute myocardial infarction[diagnosis] acute myocardial infarction Cheng ML et al. Clin Biochem. 2008
myeloperoxidase proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Esporcatte R et al. Arq Bras Cardiol. 2007
myeloperoxidase proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Dominguez-Rodriguez A et al. Am J Cardiol. 2008
myeloperoxidase proteomics no-reflow phenomenon[prognosis (bad)] acute myocardial infarction Funayama H et al. Int J Cardiol. 2010
myeloperoxidase proteomics good predictor adverse events[prognosis (bad)] acute myocardial infarction Chang LT et al. Circ J. 2009
myeloperoxidase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Goldmann BU et al. Free Radic Biol Med. 2009
myeloperoxidase proteomics reperfusion failure[prognosis (bad)] acute ST elevation myocardial infarction Karadag B et al. Heart Vessels. 2009
myeloperoxidase proteomics systemic inflammatory response syndrome[prognosis (bad)] ST elevation myocardial infarction Samimi-Fard S et al. Am J Cardiol. 2009
myeloperoxidase proteomics microvascular dysfunction[prognosis (bad)] acute ST elevation myocardial infarction Yunoki K et al. Am J Cardiol. 2010
myeloperoxidase proteomics coronary culprit lesion[other] acute ST elevation myocardial infarction Marshall CJ et al. Am J Cardiol. 2010
myeloperoxidase proteomics medium predictor acute myocardial infarction[diagnosis] acute myocardial infarction Rudolph V et al. Int J Cardiol. 2011
myeloperoxidase proteomics good predictor acute myocardial infarction[diagnosis] acute myocardial infarction Khan DA et al. Korean J Lab Med. 2011
myeloperoxidase proteomics medium predictor death[prognosis (bad)] acute ST elevation myocardial infarction Stankovic S et al. Clin Lab. 2012
myeloperoxidase proteomics death[prognosis (bad)] acute anterior ST elevation myocardial infarction Stankovic S et al. Clin Biochem. 2012
myeloperoxidase proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Kaya MG et al. Tex Heart Inst J. 2012
myeloperoxidase proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Dullaart RP et al. Atherosclerosis. 2014
myeloperoxidase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Miller CS et al. J Dent Res. 2014
myeloperoxidase proteomics cardiovascular death;heart failure[prognosis (bad)] acute ST elevation myocardial infarction O'Donoghue ML et al. J Am Heart Assoc. 2016
myeloperoxidase proteomics microvascular obstruction[prognosis (bad)] acute ST elevation myocardial infarction Stamboul K et al. PLoS One. 2017
myeloperoxidase proteomics good predictor acute myocardial infarction[diagnosis] acute myocardial infarction Omran MM et al. J Immunoassay Immunochem. 2018
myeloperoxidase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Trentini A et al. Clin Chem Lab Med. 2020
myeloperoxidase proteomics medium predictor plaque erosion[other] acute ST elevation myocardial infarction Tan Y et al. J Cardiovasc Transl Res. 2020
NM_000250.2:c.-129G>A genomics myocardial infarction[diagnosis] myocardial infarction Zotova E et al. Coron Artery Dis. 2009
myeloperoxidase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Cavusoglu E et al. Am J Cardiol. 2007
myeloperoxidase proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Schaub N et al. Clin Chem. 2012
myeloperoxidase proteomics high thrombus burden[prognosis (bad)] ST elevation myocardial infarction Niccoli G et al. Cardiology. 2017
myeloperoxidase proteomics reduced left ventricular ejection fraction[prognosis (bad)] acute anterior ST elevation myocardial infarction Helseth R et al. Cardiol Res. 2015
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